Please take note of this important update from Microsoft. If you are running Skype for Business Server or Lync Server 2013, please DO NOT install the .NET Framework 4.6.1 update that has recently been made available. Both the Exchange and Skype for Business teams are recommending against the installation of this update at this time.
For the official notice please see https://blogs.technet.microsoft.com/nexthop/2016/02/11/on-net-framework-4-6-1-and-skype-for-businesslync-server-compatibility/
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